CXCR5, the Defining Marker for Follicular B Helper T (TFH) Cells
نویسندگان
چکیده
منابع مشابه
CXCR5, the Defining Marker for Follicular B Helper T (TFH) Cells
The discovery of follicular B helper T (TFH) cells has its roots in the early 90s, the “childhood” of chemokine research that has since grown into an independent, global specialty within immunology. The class of chemoattractant proteins with shared structural features was named “chemokines,” and early work with non-chemokine (FMLP, C5a) and chemokine (IL-8/CXCL8) receptors revealed that chemoki...
متن کاملIL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.
Humoral immunity requires cross-talk between T follicular helper (Tfh) cells and B cells. Nevertheless, a detailed understanding of this intercellular interaction during secondary immune responses is lacking. We examined this by focusing on the response to a soluble, unadjuvanted, pathogen-derived Ag (soluble extract of Schistosoma mansoni egg [SEA]) that induces type 2 immunity. We found that ...
متن کاملCXCR5+CD4+ follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity.
Although many relevant immune reactions are initiated in the lymph nodes, this compartment has not been systematically studied in humans. Analyses have been performed on immune cells derived from tonsils, but as this tissue is most often inflamed, generalization of these data is difficult. Here, we analyzed the phenotype and function of the human CD4(+) T-cell subsets and lineages in paired res...
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ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B cells. Although the blockade of ICOS/B7RP-1 interaction inhibits T cell-dependent Ab production and germinal center formation, the mechanism remains unclear. We examined the contribution of ICOS/B7RP-1 to the generation of CXCR5+ follicula...
متن کاملAmé-Thomas et al. Intratumoral TFH in follicular lymphoma 1 Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells
1 INSERM, UMR 917, Rennes, F-35043, France 2 Université Rennes 1, UMR 917, Rennes, F-35043, France 3 Etablissement Français du Sang Bretagne, UMR 917, Rennes, F-35043, France 4 Centre Hospitalier Universitaire (CHU) Rennes, F-35033, France 5 INSERM, U844, Hôpital Saint-Eloi, Montpellier, F-34091, France 6 INSERM, U955, Université Paris 12, Créteil, F-94010, France 7 Hôpital Henri Mondor, Départ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2015
ISSN: 1664-3224
DOI: 10.3389/fimmu.2015.00296